Musculoskeletal Lecture Notes Essay Example

Musculoskeletal Lecture Notes Essay Musculoskeletal Physiology Be familiar with bones and muscles of body 3 types of muscle skeletal, smooth, cardiac attaches muscle to bone, decreasing angle of Joints during contraction proximal part of esophagi doesnt connect to bone, proximal (upper) conscious control is primary skeletal, distal is involuntary and smooth muscle T- tubules: inside is SEC, deep investigations of plasma membrane in muscle cell PM is sarcoma allows high concentration of Ca, like other CE spaces (ICC Is low) Ca floods into cell through T-tubules at uniform and fast rate Ca signals contraction Triads t tubes with ceroplastic respectful (also high In Ca) on each side, SIR Is resolve for Ca Ca comes In from SIR T-tubule Motor unit Neuromuscular Junction 22. 1. Skeletal muscles are all innervated by somatic nerves, conscious control Neuron goes directly to the muscle and innervated it Motor unit is a single axon and all the muscle fibers it innervates Short distance from terminal of axon and muscle fiber, d/t ACH dumped Into synaptic cleft and bind to receptors on skeletal muscle, when Ach withdrawn muscle relaxes Nerve Impulse down axon, when hits the Exxon terminus It causes a voltage gated Ca channel to pen, wave of depopulation causes Ca to come Into cell (Ca tells cells to do what It does best) and axon terminus releases Its neurotransmitters. ACH) ACH vesicle fuses with plasma membrane, what was inside the vesicle Is now outside the cell, ACH drifts across synaptic cleft to bind to an ACH channel, when 2 Aches bind the channel opens, this allows An to move into the muscle fiber. An wants to go into cell anyways (+ inside). An floods into cell causing muscle fiber to deplorable, causing voltage gated An channel causing further deportation. Ultimately causing voltage dated Ca channel on a T-tubule to open, then Ca flows into cytoplasm from SIR. Rapid influx of Ca throughout muscle cell. We will write a custom essay sample on Musculoskeletal Lecture Notes specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Musculoskeletal Lecture Notes specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Musculoskeletal Lecture Notes specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Ca channels: 1) Voltage gated Ca channel also called: DIP receptors, on T tubule, open d/t deportation of sarcoma. 2) Ca induced Ca channels = reloading channels which are on the SIR and open In response to DIP receptors allowing Ca to come In from SIR. During popularization the Ca gets pumped back Into SIR to Walt for next deportation Muscle Contraction 22. 1. 3 Acting: globular protein thats forms together to make a filament Transmission: small sections that form together and bind to acting at specific place. @ rest covers myosin binding site Trooping: bound to tromping. Parts, l: Ignore C: binds to Ca when it comes into cell T: binds to tromping. When Ca binds to trooping, causes trooping to move tromping exposing the myosin binding site Myosin can now bind to acting, muscle contracts 4 steps to muscle contraction 1 . Myosin head bind to acting filament that has been uncovered, causing release of Phosphate 2. Head of bound myosin flicks, moves one acting globulin, this is the powe r stroke 3. TAP binds to acting head, allowing release of, requires and TAP 4. TAP is hydroxide and head is repositioned As long as Ca is available this will occur. If muscle runs out of TAP = release cant happen = rigor Morris Muscle Fiber Types, Injury Repair 22. 1. 4 Slow oxidative Type 1 more TAP is hydrazine in reposition stage, happens slow high fatigue resistance, lots of oxidative compatibility, aerobic makes TAP as needs it more mitochondria b/c it needs it more myosin RED dark meat (legs walk a lot) doesnt need to store a lot of glycogen smaller and weaker fibers recruit these smaller motor units first Fast oxidative Type AAA Fast glaciology Type b less TAP is hydrazine in reposition stage, happens fast (lox faster) low fatigue resistance, slow oxidative compatibility, anaerobic, blows through TAP fast few mitochondria few capillaries and myosin WHITE breast (wings- seldom) high glycogen content (glycoside) larger and stronger recruit these larger motor units less often Denigrate and innervate (spinal cord injury) other axons will re-innervate those that have been devastated, less fine control Karri poison dart frog Blocks ACH receptor, powerful neuromuscular blockade Colostomies Botulism Causes ACH vesicles to not fuse with PM bottom paralyze muscles, half life is a month or so Colostomies Tennis EXCESSIVE release of ACH, muscle tenses, EX: lock Jaw Mechanical Disorders of the Bone 23. 1. 2 Arthritis- Osteoarthritis Gout Bursitis inflammation of bursa Bone Cancer 1% Dislocation movement of bone out of normal position, no tendon injury Sprains injury to Joint that involves ligament damage Strain occurs to muscles or tendons Fractures Oblique: oblique angle Occult: difficult to visualize, neck of femur Open: skin has been penetrated Pathologic: secondary to another disease EX: CA Segmented: broken into multiple pieces Spiral: oblique angle but spirals, result of twisting force Transverse: straight across Cricketing: cortex is only broken on one side, break doesnt go all the way through Impacted: two ends impacted, pushed one end into other Repair: Casts, external fixation may be needed so pin goes through bone (ankles holds tarsal anchored to tibia) Syphilis- compression fractures, older woman, hump Loriss pregnant women, wet pulls lumbar vertebrae forward increase curvature Scoliosis teenage girls, S-shaped back Treatment: surgery to place intertribal rods Osteoporosis 23. . 3 Osteoporosis loss of bone mass, traceable bone (spongy bone) lots in vertebrates Thinner cortex Estonian: precursor to osteoporosis, some bone loss Women affects men less 1. Men have larger bone mass to begin with 2. Menopause increases rate of bone loss 3. Men die younger, dont have a chance to loss the bone Males continue to produce bone at almost same rate as it is being reabsorbed Descant: X-rays through bone to see attenuation of bones,